​​​​妊活に関する正しい情報が学べるサイト。元ハーバード大学産婦人科講師が、あなたの妊活をサポートします!

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​​産婦人科医 樽井智子の妊活手帳

1999年7月 世界体外受精会議記念学会賞 受賞
2001年3月 山形大学大学院ベンチャービジネスラボラトリー研究奨励賞
2002年9月~2003年3月 厚生労働科学研究 母子保健、成育医療フェローシップ 日本人研究者派遣事業 派遣研究者
2003年 Lalor Foundation Postdoctoral Travel Fellowship, 36th Annual Meeting of the Society for the Study of Reproduction
2004年 上原記念生命財団 海外留学助成金ポストドクトラルフェローシップ

著書

受賞歴

1.   Fujii J, Kaneko T, Kobayashi T, Iuchi Y, Takahashi M (2002) Localization and Physiological Implication of Polyol- Metabolyzing Enzymes in Male and Female Reproductive Systems of Rat. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era. ( Horiuchi S, Kurata T, Taniguchi N, Osawa T, Hayase F Eds), Elsevier 363-364.

2.   Fujii J, Kaneko T, Iuchi Y (2002) Glutathione Redox Status in the Rat Reproductive System. XI Biennial Meeting of the Society for Free Radical Research International (C.Pasquier ed), C716: 217-220

Achivement 業績

英文原著論文

1.   Moreira P, Saito H, Kaneko T, Saito T, Nakahara K, Hiroi M (1999) Are there any relations between the fecundity of the bilateral ovaries in an individual patient and the incidence of apoptotic granulosa cells? Hum Reprod 14(1): 156-161

2.   Zhao S, Saito H, Wang X, Saito T, Kaneko T, Hiroi M (2000) Effects of gonadotropin-releasing hormone agonist on the incidence of apoptosis in porcine and human granulosa cells. Gynecol Obstet Invest 49: 52-59

3.   Toya M, Saito H, Ohta N, Saito T, Kaneko T, Hiroi M (2000) Moderate and severe endometriosis is associated with the alternation of the cell cycle of granulosa cells in patients involved in an in vitro fertilization and embryo transfer program. Fertil Steril 73 (2): 344-350

4.   Sadraie SH, Saito H, Kaneko T, Saito T, Zhao S, Hiroi M (2000) Effects of aging on ovarian fecundity in terms of the incidence of apoptotic granulosa cells.  J Assist Reprod Genet 17(3):168-1173

5.   Ohta N, Saito H, Kaneko T, Yoshida M, Takahashi T, Saito T, Nakahara K, Hiroi M (2000) Soluble CD44 in human ovarian follicular fluid. J Assist Reprod Genet 18:23-27     

6.   Saito H, Ishida GM, Kaneko T, Kawachiya S, Ohta N, Takahashi T, Saito T, Hiroi M (2000) Application of vitrification to human embryo freezing. Gynecol Obstet Invest 49(3):145-149

7.   Saito H, Saito T, Kaneko T, Sasagawa I, Kuramoto T, Hiroi M (2000) Relatively poor oocyte quality is an indication for intracytoplasmic sperm injection. Fertil Steril 73(3): 465-469

8.   Kaneko T, Saito H, Toya M, Saito T, Nakahara K, Hiroi M (2000) Hyaluronic acid inhibits apoptosis in granulosa cells via CD44. J Assist Reprod Genet 17(3): 162-167

9.   Saito H, Kaneko T, Takahashi T, Kawachiya S, Saito T, Hiroi M (2000) Hyaluronan In follicular fluids and fertilization of oocytes. Fertil Steril 74:1148-1152

10. Kaneko T, Saito H, Takahashi T, Ohta N, Saito T, Hiroi M (2000) Effects of ovarian hyperstimulation on oocyte quality in terms of the incidence of apoptotic granulosa cells.  J Assist Reprod Genet 17(10):580-585

11. Kaneko T, IuchiY, Kawachiya S, Fujii T, Saito H, Kurachi H and Fujii J (2001) Alteration of Glutathione Reductase Expression in the Female Reproductive Organs during the Estrous Cycle. Biol Reprod 65: 1410-1416

12.  Iuchi Y, Kobayashi T, Kaneko T, Takahara M, Ogino T, Fujii J (2001) The expression of a Y-box protein, YB2/RYB-a precedes protamine 2 during spermatogenesis in rodents. Mol Hum Reprod, 7(11): 1023-31

13. Kaneko T, Iuchi Y, Kobayashi T, Fujii T, Saito H, Kurachi H, and Fujii J (2002) Expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis.  Eur J Biochem 269(5):1570-8

14. Saito H, Seino T, Kaneko T, Nakahara K, Toya M, Kurachi H (2002)  Endometriosis and Oocyte Quality  Gynecol Obsett Invest  53 suppl 1: 46-51

15. Seino T, Saito H, Kaneko T, Takahashi T, Kawachiya S, and Kurachi H (2002) Eight-hydroxy-2’-deoxyguanosine in granulosa cells reduces the quality of oocytes and embryos during an in vitro fertilization and embryo transfer program. Fertil Steril 77(6): 1184-90

16. Kobayashi T, Kaneko T, Iuchi Y, Matsuki S, Takahashi M, Sasagawa I, Nakada T and Fujii J (2002) localization and physiological implication of aldose reductase and sorbitol dehydrogenase in male reproductive system, accessory glands, and spermatozoa of rats.  J Androl 23(5): 674-83

17. Iuchi Y, Kaneko T, Matsuki S, Sasagawa I, Fujii J (2003) Concerted changes in the YB2/RYB-a protein  and protamine 2 messenger RNA in the mouse testis under heat stress. Biol Reprod, 68(1): 129-35

18. Kaneko T, Iucui Y, Takahashi M, Fujii J (2003) Colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the rat. Histochem Cell Biol, 119: 309-315

19. Iuchi Y, Kaneko T, Matsuki S, Ishii T, Ikeda Y, Fujii J (2004) Carbonyl stress and detoxification ability in the male genital tract and testis of rats. Histochem Cell Biol, 121:123-130

20. Johnson J, Canning J, Kaneko T, Pru J, Tilly JL (2004) Germline stem cells and follicular repopulation in the postnatal mammalian ovary. Nature, 428: 145-150

21.Skaznik-Wikiel ME, Kaneko-Tarui T, Kashiwagi A, Pru JK (2006). Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy. Biol Reprod, 74(3): 569-76

22. Skaznik-Wikiel M, Tilly JC, Lee HJ, Niikura Y, Kaneko-Tarui T, Johnson J, Tilly JL (2007) Serious doubts over “Eggs forever?” Differentiation, 75 (2): 93-99

23. Kaneko-Tarui T, Zhang L, Austin KJ, Henkes LE, Johnson J, Hansen TR, Pru J (2007) Maternal and embryonic control of uterine sphingolipid-metabolizing enzymes during murine embryo implantation. Biol Reprod, 77(4): 658-62

24. Pru J, Kaneko-Tarui T, Jurisicova A, Kashiwagi A, Selesniemi K, Tilly JL (2009) Induction of pro-apoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons. Reproductive Sciences, 16(4):347-56.

25. Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J (2010) Constitutive WNT/Beta-catenin signaling in murine sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod, 2010 Feb;82(2):422-32.

26. Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, Roberts DJ, Teixeira JM (2011) Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN. PLOS. 2011 vol. 6 (6) pp. e20715

27. Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Lee HJ, Teixeira JM (2012) Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility. Endocrinol, 153 (1) 404-416

28. Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM (2012) Altered LKB1/ AMPK/ TSC1/ TSC2/ mTOR signaling causes disruption of Sertoli cell polarity andspermatogenesis. Hum Mol Genet, Oct 15;21(20):4394-405.

29. Tanwar PS*, Kaneko-Tarui T*, Zhang L, Teixeira JM (2012) Stromal Liver Kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian target of rapamycin complex 1. PLoS Genetics, 8(8):e1002906. (*Co-first authors)

30. Tanwar PS, Kaneko-Tarui T, Lee HJ, Zhang L, Teixeira JM (2013) PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression. Carcinogenesis, Apr;34(4):893-901

31. Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, Ohguchi Y, Birrer MJ, Teixeira JM (2014) Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epothelium induced papillary serous ovarian cancer. Carcinogenesis, Mar;35(3):546-53.

32. Kaneko-Tarui T, Commandeur AE, Patterson AL, DeKuiper JL, Petillo D, Styer AK, Teixeira JM (2014) Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria.

2014.8.31 第12回 東北ART研究会 招請講演 『米国のARTを取り巻く現状』, Sendai, Japan

2013.10.5『子宮頸癌とその予防ワクチンについて』 Japanese Language School of Boston, Medford, MA, USA

2013.8.4 Super Science Highschool students visit『女性研究者としての生き方〜女性のキャリアパスについて〜』Boston, MA, USA

2012.10.18 JWCB講演 「更年期の女性の健康と、女性に対するHPVワクチン接種の意義」Watertown, MA, USA

2012.8.5 Super Science Highschool students visit『女性研究者としての生き方』Boston, MA, USA

2009.11.21 婦人科セミナー『更年期を快適に過ごすために』Japanese Language School of Boston, Medford, MA, USA

講演